Dr Karl Frontzek


Dr Karl Frontzek is an experienced pathologist who possesses vast expertise in various aspects of neuropathology. His research encompasses a wide range, from fundamental investigations into dementias to unraveling the intricate molecular mechanisms and exploring innovative therapeutic strategies. Additionally, he holds specialized knowledge in forensic neuropathology as well as pathology of adult and paediatric neuromuscular diseases. Dr Frontzek has been appointed as Clinical Associate Professor of Neuropathology and Honorary Consultant Neuropathologist since March 2023.

Languages Spoken:

  • German, Polish, French


Pathology of neuromuscular and central nervous system diseases

Neuromuscular Diseases Neurodegenerative Diseases


2017 PhD, University of Zurich, Switzerland
2014 MD, University of Basel, Switzerland
2010 Human Medicine, University of Goettingen, Germany

Licenses and certifications

2022 Specialist in Diagnostic Neuropathology (United Kingdom) 2021 Full license to practise medicine (United Kingdom)
2019 Board certification in Neuropathology (Switzerland)
2011 Full license to practise medicine (Switzerland)

2011 Full license to practise medicine (Germany)

Professional Memberships

Swiss Society of Neuropathology British Neuropathological Society

Dr Frontzek's research interests primarily lie in the realm of basic science related to neurodegenerative diseases, with a particular focus on understanding the neuroimmune components of neurodegeneration. Through molecular and biochemical investigations conducted on brain tissue from individuals afflicted with Alzheimer's and Parkinson's diseases, his aim is to uncover critical insights into the underlying pathological mechanisms. His ultimate goal is to utilise this knowledge to devise groundbreaking therapeutic approaches that can effectively combat these devastating disorders and potentially offer new avenues for treating neurodegenerative conditions.

News & Publications

Frontzek, K; et al. A conformational switch controlling the toxicity of the prion protein. (2022) Nature Structural & Molecular Biology
Lakkaraju, AKK; Frontzek, K; et al. Loss of PIKfyve drives the spongiform degeneration in prion diseases. (2021) EMBO molecular medicine Kirschenbaum, D; [...]; Frontzek, K. Intracerebral endotheliitis and microbleeds are neuropathological features of COVID‐19. (2021)Neuropathology and applied neurobiology

Frontzek, K; et al. Autoantibodies against the prion protein in individuals with PRNP mutations. (2020) Neurology
Kirschenbaum, D; [...]; Frontzek, K. Inflammatory olfactory neuropathy in two patients with Covid-19. (2020) The Lancet

Senature, A; Frontzek, K; et al. Protective anti-prion antibodies in human immunoglobulin repertoires. (2020) EMBO Molecular Medicine
Zhu, C; Li, B; Frontzek, K; et al. SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. (2019) Journal of Experimental Medicine

Bardelli, M; Frontzek, K; et al. A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity. (2018) PLoS pathogens
Frontzek, K; et al. Amyloid-β pathology and cerebral amyloid angiopathy are frequent in iatrogenic Creutzfeldt-Jakob disease after dural grafting. (2016) Swiss medical weekly

Frontzek, K; et al. Neurotoxic antibodies against the prion protein do not trigger prion replication. (2016) PloS one

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