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طبيب Sara Ghorashian

Consultant Paediatric Haematologist and Honorary Senior Lecturer

نظرة عامة

Sara Ghorashian qualified from Oxford University and undertook haematology training at the Hammersmith and Royal Free Hospitals. She obtained a PhD at University College London (UCL) in the use of gene-engineered T cells for cancer immunotherapy. More recently, her post-doctoral studies at the UCL Great Ormond Street Institute of Child Health involved translation of CD19CAR T cells as therapy for childhood acute lymphoblastic leukaemia (ALL) from bench to bedside. Her research interests are cellular immunotherapy for haematological malignancies and T cell immunobiology.

She has clinical interests in paediatric malignant haematology, and leads on cell therapy and research within the department. She is a co-investigator on two CAR T cell studies for ALL, and actively involved in implementing new studies in order to improve outcomes for children with high risk or relapsed haematological malignancies.


  • Paediatric malignant haematology
  • Cellular therapy for haematological malignancies
  • Development and optimisation of cellular therapies for haematological malignancies

  • BMBCh - Medicine (Oxford University)
  • MA (Hons) – Physiological Sciences (Oxford University)
  • MRCP - Royal College of Physicians, London
  • PhD – Immunology
  • FRCPath – Royal College of Pathologists, London



  • Development and optimisation of cellular therapies for haematological malignancies
  • T cell immunobiology

الأخبار والمنشورات

Khan AB, Carpenter B, Sousa PSE, Pospori C, Khorshed R, Griffin J, Veliça P, Zech M, Ghorashian S, et. al.  Redirection to the bone marrow improves T cell persistence and antitumor functions. J Clin Invest. doi: 10.1172/JCI97454 (epub ahead of print)

Vormittag P, Gunn R, Ghorashian S, Veraitch FS. A guide to manufacturing CAR T cell therapies. Curr Opin Biotechnol.53:164-181.

Rossig C, Pule M, Altvater B, Saiagh S, Wright G, Ghorashian S., et al. Vaccination to improve the persistence of CD19CAR gene-modified T cells in relapsed pediatric acute lymphoblastic leukemia. Leukemia. DOI: 10.1038/leu.2017.39. 

Qasim W, Zhan H, Samarasinghe S, Adams S, Amrolia P, Stafford S, Butler K, Rivat C, Wright G, Somana K, Ghorashian S., et al. Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells. Science and Translational Medicine. 9(374). doi: 10.1126/scitranslmed.aaj2013. 

Holler A., Zech M., Ghorashian S., Pike R., et al. Expression of a dominant T cell receptor can reduce toxicity and enhance tumour protection of allogeneic T cell therapy. Haematologica, 101(4):482-90. 

Ghorashian, S., Pule, M., Amrolia, P. CD 19 chimeric antigen receptor therapy for haematological malignancies. British Journal of Haematology. 169(4), 463-78 

Ghorashian, S., Velica, P., Chua, I., McNicol, A-M., et al. CD8 T cell tolerance to a tumour associated self antigen is reversed by CD4 T cells engineered to express the same T cell receptor. Journal of Immunology 194(3), 1080-9 

Buchan, S.L., Manzo, T., Flutter, B., Rogel, A., Edwards, N., Zhang, L., Sivakumaran, S., Ghorashian, S., et al. OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ cells to exit quiescence. Journal of Immunology, 194(1), 125-33 

Zimbarra Cabrita, I., Abubaker, M., Layton, M., Ghorashian, S., et al. The association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdom. British Journal of Haematology, 162(3): 400-408. 

Xue, S.-A., Gao, L., Ahmadi, M., Ghorashian, S., et al. Human MHC Class I-restricted high avidity CD4+ T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo. Oncoimmunology 2 (1), e22590 

Nicholson, E., Ghorashian, S., & Stauss, H. Improving TCR Gene Therapy for Treatment of Haematological Malignancies. Advances in Hematology, 2012, 404081 

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