Giuseppe Barone 医生

小儿肿瘤学专家
Dr Barone

概述

朱塞佩.巴罗内医生是一名专长于神经母细胞瘤和新药开发的小儿肿瘤学专家医师。自2016年7月起,他开始担任大奥蒙德街儿童医院神经母细胞瘤的临床领头人。他曾经在美国贝塞斯达国立癌症研究所进行癌症治疗评估项目,以及在英国伦敦的皇家马斯登医院/研究所开展针对癌症的研究。

巴罗内医生在伦敦癌症研究院/学院完成了博士学位。他的研究针对于评估神经母细胞瘤的生物学方面,并在该疾病中试验有效的新药。

相关资质

  • 神经母细胞瘤
  • 肝母细胞瘤
  • 肾母细胞瘤
  • 朗格汉斯细胞组织细胞增生症(旧称:组织细胞增生症)

教育背景:

  • 2016年,英国伦敦癌症研究所分子生物学和癌症治疗学博士 
  • 2009年,意大利罗马杰梅利医院圣心天主教大学儿科/儿童肿瘤学学位
  • 2004年,意大利罗马杰梅利医院圣心天主教大学外科与药学学士学位 

成员资质:

  • 皇家儿科与儿童健康学院 RCPCH (Royal College of Paediatrics and Child Health)
  • 产业与组织心理学会-欧洲部神经母细胞瘤小组 SIOPEN (SIOP- Europe - Neuroblastoma Group)
  • 癌症儿童创新治疗联盟  ITCC (Innovative Treatment for Children with Cancer Consortium)
  • 神经母细胞瘤生物学
  • 小分子学
  • 免疫疗法

新闻和论文发表

Barone, G., Tweddle, D.A., Shohet, J.M., Chesler, L., Moreno, L., Pearson, A.D., Van Maerken, T., 2014.  MDM2-p53 interaction in paediatric solid tumours: preclinical rationale, biomarkers and resistance. Current Drug Targets. 15 (1) pp. 114-123.

Barone, G., Anderson, J., Pearson, A.D.K., Chesler, L., 2013. New strategies in neuroblastoma: Therapeutic targeting of MYCN and ALK. Clin Cancer Res. 19 (21) pp. 5814-5821.

Riccardi, R*., Barone, G*., 2009. Severe infections in immunodepressed children. Minerva Pediatrica. 61 (6) pp. 854-856. (* joint first Authors)

Basta NO, Halliday GC, Makin G, Birch J, Feltbower R, Bown N, Elliott M, Moreno L, Barone G, Pearson AD, James PW, Tweddle DA, McNally RJ. Factors associated with recurrence and survival length following relapse in patients with neuroblastoma.Br J Cancer. 2016 Oct 25;115(9):1048-1057

Morgenstern DA, Hargrave D, Marshall LV, Gatz SA, Barone G, Crowe T, Pritchard-Jones K, Zacharoulis S, Lancaster DL, Vaidya SJ, Chisholm JC, Pearson AD, Moreno L. Toxicity and outcome of children and adolescents participating in phase I/II trials of novel anticancer drugs: the Royal Marsden experience. J Pediatr Hematol Oncol 2014, 36 (3), 218-223.

Moreno, L., Barone, G., Park, J. R., & Pearson, A. D. (2013). About the benefits of immunotherapy for high-risk neuroblastoma. J Clin Oncol, 31(5), 649-650. doi:10.1200/JCO.2012.47.4080

Moreno, L., Caron, H., Geoerger, B., Eggert, A., Schleiermacher, G., Brock, P., . . . Pearson, A. D. (2017). Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project. Expert Opin Drug Discov, 12(8), 801-811. doi:10.1080/17460441.2017.1340269

Di Francesco, A. M., Meco, D., Torella, A. R., Barone, G., D'Incalci, M., Pisano, C., . . . Riccardi, R. (2007). The novel atypical retinoid ST1926 is active in ATRA resistant neuroblastoma cells acting by a different mechanism. Biochemical pharmacology, 73(5), 643-655. doi:10.1016/j.bcp.2006.10.033

Di Francesco, A. M., Riccardi, A., Barone, G., Rutella, S., Meco, D., Frapolli, R., . . . Riccardi, R. (2005). The novel lipophilic camptothecin analogue gimatecan is very active in vitro in human neuroblastoma: a comparative study with SN38 and topotecan. Biochemical pharmacology, 70(8), 1125-1136. doi:10.1016/j.bcp.2005.07.009

Di Francesco, A. M., Ubezio, P., Torella, A. R., Meco, D., Pierri, F., Barone, G., . . . Riccardi, R. (2012). Enhanced cell cycle perturbation and apoptosis mediate the synergistic effects of ST1926 and ATRA in neuroblastoma preclinical models. Invest New Drugs, 30(4), 1319-1330. doi:10.1007/s10637-011-9689-2

Moreno, L., Barone, G., Park, J. R., & Pearson, A. D. (2013). About the benefits of immunotherapy for high-risk neuroblastoma. J Clin Oncol, 31(5), 649-650. doi:10.1200/JCO.2012.47.4080

Moreno, L., Caron, H., Geoerger, B., Eggert, A., Schleiermacher, G., Brock, P., . . . Pearson, A. D. (2017). Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project. Expert Opin Drug Discov, 12(8), 801-811. doi:10.1080/17460441.2017.1340269

Morgenstern, D. A., Hargrave, D., Marshall, L. V., Gatz, S. A., Barone, G., Crowe, T., . . . Moreno, L. (2014). Toxicity and outcome of children and adolescents participating in phase I/II trials of novel anticancer drugs: the Royal Marsden experience. J Pediatr Hematol Oncol, 36(3), 218-223. doi:10.1097/MPH.0000000000000003

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