Dr Sarita Depani

Consultant Paediatric Oncologist


Dr Sarita Depani joined Great Ormond Street Hospital (GOSH) in January 2022 as a Consultant Paediatric Oncologist.  Prior to this she spent just over a year working as a Consultant Paediatric Oncologist at University Hospital Southampton and 5 months as locum Consultant at GOSH.

Dr Depani completed her speciality training in paediatric oncology at GOSH, the Royal Marsden Hospital and University College London Hospital.  She spent two years as a Cancer Research UK Clinical Trials Fellow working between GOSH and the Cancer Research UK Clinical Trials Unit at the University of Birmingham.  She worked on a number of early and late phase studies, submitted two successful CRUK grant applications for ESMART and AGCT1531 and worked as a drug development fellow at GOSH looking after patients enrolled on commercial and academic Phase I/II studies.

Dr Depani specialises in paediatric neuro-oncology (tumours of the brain and spine) and paediatric germ-cell tumours.  She is a member of the UK Children’s Cancer and Leukaemia (CCLG) Neuro-oncology special interest group and is a member of the CCLG Germ Cell tumour National Advisory Panel.

Dr Depani says:  ‘I aim to provide the very best care for my patients by liaising with national and international experts to ensure the most up-to-date and comprehensive diagnostic and treatment plan.  I take pride in building excellent relationships with my patients and their families.’

Languages Spoken:

  • English, Gujrati


Paediatric Oncology – solid tumours specifically:

Paediatric Neuro-Oncology

Paediatric Germ Cell Tumours

Paediatric Oncology

Paediatric Neuro-Oncology

Paediatric Germ Cell Tumours


MBBS University College London, 2004

Membership of Royal College of Paediatrics and Child Health, 2008

Masters in Clinical Paediatrics, Institute of Child Health, University of London, 2012



National Sub-specialty GRID training in Paediatric Oncology 2012-2019

Cancer Research Clinical Trials Fellow 2016-2018

Member of the Children Cancer and Leukaemia Group (CCLG)

Member of the CCLG Neuro-oncology Special Interest Group

Member of the CCLG Germ Cell Tumour Special Interest Group and National Advisory Panel

Member of Malignant Germ Cell International Consortium (MaGIC)

Member of SIOP Europe

Germ Cell Tumours

Novel therapeutics and drug development

News & Publications


Straathof K, Flutter B, Wallace R, Jain N, Loka T, Depani S, Wright G, Thomas S, Cheung GW, Gileadi T, Stafford S, Kokalaki E, Barton J, Marriott C, Rampling D, Ogunbiyi O, Akarca AU, Marafioti T, Inglott S, Gilmour K, Al-Hajj M, Day W, McHugh K, Biassoni L, Sizer N, Barton C, Edwards D, Dragoni I, Silvester J, Dyer K, Traub S, Elson L, Brook S, Westwood N, Robson L, Bedi A, Howe K, Barry A, Duncan C, Barone G, Pule M, Anderson J. Antitumor activity without on-target off-tumor toxicity of GD2-chimeric antigen receptor T cells in patients with neuroblastoma. Sci Transl Med. 2020 Nov 25;12(571):eabd6169. doi: 10.1126/scitranslmed.abd6169. PMID: 33239386.

Phillips B, Depani S, Morgan J. What do families want to improve in the management of paediatric febrile neutropenia during anti-cancer treatment? Report of a patient/public involvement group. BMJ Paediatr Open. 2019 Mar 1;3(1):e000398.

Depani S, Stoneham S, Krailo M, Xia C, Nicholson J. Results from the UK Children's Cancer and Leukaemia Group study of extracranial germ cell tumours in children and adolescents (GCIII). Eur J Cancer. 2019 Sep;118:49-57.


George SL, Izquierdo E, Campbell J, Koutroumanidou E, Proszek P, Jamal S, Hughes D, Yuan L, Marshall LV, Carceller F, Chisholm JC, Vaidya S, Mandeville H, Angelini P, Wasti A, Bexelius T, Thway K, Gatz SA, Clarke M, Al-Lazikani B, Barone G, Anderson J, Tweddle DA, Gonzalez D, Walker BA, Barton J, Depani S, Eze J, Ahmed SW, Moreno L, Pearson A, Shipley J, Jones C, Hargrave D, Jacques TS, Hubank M, Chesler L. A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations. Eur J Cancer. 2019 Nov;121:224-235

Macken M, Dale H, Moyo D, Chakmata E, Depani S, Israels T, Niyrenda D, Bailey S, Chagaluka G, Molyneux EM. Triple therapy of vincristine, bleomycin and etoposide for children with Kaposi sarcoma: Results of a study in Malawian children. Pediatr Blood Cancer. 2018 Feb;65(2). doi: 10.1002/pbc.26841. Epub 2017 Oct 8. PMID: 28988435.

Molyneux E, Schwalbe E, Chagaluka G, Banda K, Israels T, Depani S, Mittermayer-Vassallo K, Windebank K, Mvula J, Njiram'madzi J, O'Brien S, Carey P, Bailey S. The use of anthracyclines in the treatment of endemic Burkitt lymphoma. Br J Haematol. 2017 Jun;177(6):984-990. doi: 10.1111/bjh.14440. Epub 2016 Nov 28. PMID: 27891583.

Shankar AG, Kirkwood AA, Depani S, Bianchi E, Hayward J, Ramsay AD, Hall GW. Relapsed or poorly responsive nodular lymphocyte predominant Hodgkin lymphoma in children and adolescents - a report from the United Kingdom's Children's Cancer and Leukaemia Study Group. Br J Haematol. 2016 May;173(3):421-31

Depani S, Banda K, Bailey S, Israels T, Chagaluka G, Molyneux E. Outcome is unchanged by adding vincristine upfront to the Malawi 28-day protocol for endemic Burkitt lymphoma. Pediatr Blood Cancer. 2015 Nov;62(11):1929-34.


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